The Copper Chaperone CCS Directly Interacts with Copper/Zinc Superoxide Dismutase
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چکیده
منابع مشابه
Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase.
Oxidative stress leads to the up-regulation of many antioxidant enzymes including Cu,Zn superoxide dismutase (SOD1) via transcriptional mechanisms; however, few examples of posttranslational regulation are known. The copper chaperone for SOD1 (CCS) is involved in physiological SOD1 activation, and its primary function is thought to be delivery of copper to the enzyme. Data presented here are co...
متن کاملCharacterization of the Recombinant Copper Chaperone (CCS) for the Copper/Zinc Superoxide Dismutase (CuZnSOD) from the plant Glycine (G.) max
Estación Experimental de Aula Dei (EEAD), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Montañana 1005, E-50059 Zaragoza, Spain ([email protected];[email protected];[email protected];[email protected]). Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias and Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zar...
متن کاملCopper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase.
Recent studies in Saccharomyces cerevisiae suggest that the delivery of copper to Cu/Zn superoxide dismutase (SOD1) is mediated by a cytosolic protein termed the copper chaperone for superoxide dismutase (CCS). To determine the role of CCS in mammalian copper homeostasis, we generated mice with targeted disruption of CCS alleles (CCS(-/-) mice). Although CCS(-/-) mice are viable and possess nor...
متن کاملHeterodimer formation between superoxide dismutase and its copper chaperone.
Copper, zinc superoxide dismutase (SOD1) is activated in vivo by the copper chaperone for superoxide dismutase (CCS). The molecular mechanisms by which CCS recognizes and docks with SOD1 for metal ion insertion are not well understood. Two models for the oligomerization state during copper transfer have been proposed: a heterodimer comprising one monomer of CCS and one monomer of SOD1 and a dim...
متن کاملA copper chaperone for superoxide dismutase that confers three types of copper/zinc superoxide dismutase activity in Arabidopsis.
The copper chaperone for superoxide dismutase (CCS) has been identified as a key factor integrating copper into copper/zinc superoxide dismutase (CuZnSOD) in yeast (Saccharomyces cerevisiae) and mammals. In Arabidopsis (Arabidopsis thaliana), only one putative CCS gene (AtCCS, At1g12520) has been identified. The predicted AtCCS polypeptide contains three distinct domains: a central domain, flan...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.37.23625